Diabetes, oxidative stress, and antioxidants: a re... [J Biochem Mol Toxicol. 2003] - PubMed result

Diabetes, oxidative stress, and antioxidants: a re... [J Biochem Mol Toxicol. 2003] - PubMed result: "J Biochem Mol Toxicol. 2003;17(1):24-38.
Diabetes, oxidative stress, and antioxidants: a review.
Maritim AC, Sanders RA, Watkins JB 3rd.

Moi University, College of Health Sciences, Eldoret, Kenya.
Abstract
Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. Abnormally high levels of free radicals and the simultaneous decline of antioxidant defense mechanisms can lead to damage of cellular organelles and enzymes, increased lipid peroxidation, and development of insulin resistance. These consequences of oxidative stress can promote the development of complications of diabetes mellitus. Changes in oxidative stress biomarkers, including superoxide" dismutase, catalase, glutathione reductase, glutathione peroxidase, glutathione levels, vitamins, lipid peroxidation, nitrite concentration, nonenzymatic glycosylated proteins, and hyperglycemia in diabetes, and their consequences, are discussed in this review. In vivo studies of the effects of various conventional and alternative drugs on these biomarkers are surveyed. There is a need to continue to explore the relationship between free radicals, diabetes, and its complications, and to elucidate the mechanisms by which increased oxidative stress accelerates the development of diabetic complications, in an effort to expand treatment options.
*********************************************************************************
Bill's comments
*********************************************************************************
Do you think that their "effort to expand treatment options" would include an alkaline diet or Ionized water? Naaah, no profit in vegetables and water!

Fast Food Will Kill You!

A small McDonald’s meal that topped out at 900 calories was studied for its oxidation potential. The findings were not encouraging for fans of fast food.

“We showed that a small McDonald’s meal resulted in inflammation and oxidative stress at a cellular, molecular level,” says Dr. Dandona. The markers Dr. Dandona and his team used to establish the presence of inflammation and oxidative stress are the same ones the body produces when it is seriously hurt. “In the cells, we look at nuclear factor kB (NF-kappa B), which is the orchestrator of inflammation. When we get infections, it is NF-kappa B that gets stimulated,” he explains. “We were shocked to find that what infections do, food does, too.” Disturbingly, the post-meal inflammatory reaction did not resolve quickly — study subjects still showed signs of inflammation five hours after eating.

Dr. Dandona’s research also found that people with obesity who already had a basic level of inflammation and oxidative stress had a worse reaction than people of normal weight when challenged with a fast-food meal. “Sure enough, they start from higher levels of inflammation, they achieve a much higher level, and the inflammation is much more prolonged.” The oxidative and inflammatory stress observed with meals probably contributes to atherosclerosis, heart attack, and stroke.

Paresh Dandona, MD, Director of the Diabetes-Endocrinology Center of Western New York and Chief of the Division of Endocrinology at the Medical School of the State University of New York at Buffalo.
************************************************************************************
Bill's Comments
************************************************************************************

There you have it. McDonald's meals and similar processed, chemical filled fast food fare can kill you! Oxidative stress from the free radicals produced by the metabolism of this faux food attacks the body's cell walls, cell proteins and DNA, leading to everything from artherosclerosis to cancer to Alzheimers disease.

The news is doubly bad for fat people. You were Warned!